Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke: a meta-analysis of controlled trials
“Objective: The aim of this study was to evaluate the efficacy and safety of the mesenchymal stem cell (MSC) therapy in patients with ischemic stroke (IS).
Materials and methods: Clinical trials involved in this research were searched from PubMed, Web of Science, Cochrane Library, Embase, Wanfang and CNKI database. Therapeutic effects of MSC therapy were assessed according to National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI), Fugl-Meyer Assessment (FMA) and Functional Independence Measure (FIM), and its safety was evaluated based on adverse events.
Results: This research covered 23 trials including 1,279 IS patients. Based on our analysis, the overall condition of IS patients significantly improved after MSC therapy, indicated by decreased NIHSS and increased BI, FMA and FIM scores. Our analysis also showed that the treatment effects in the MSC transplantation group were superior to those in the control group (routine medication therapy) with statistical significance for NIHSS (1 month after therapy: odds ratio [OR]=-1.92, CI=-3.49 to -0.34, P=0.02; 3 months after therapy: OR=-2.65, CI=-3.40 to -1.90, P<0.00001), BI (1 month after therapy: OR=0.99, CI=0.19–1.79, P=0.02; 6 months after therapy: OR=10.10, CI=3.07–17.14, P=0.005), FMA (3 months after therapy: OR=10.20, CI=3.70–16.70, P=0.002; 6 months after therapy: OR=10.82, CI=6.45–15.18, P<0.00001) and FIM (1 month after therapy: OR=15.61, CI=-0.02 to 31.24, P=0.05; 6 months after therapy: OR=16.56, CI=9.06–24.06, P<0.0001). No serious adverse events were reported during MSC therapy.
Conclusion: MSC therapy is safe and effective in treating IS by improving the neurological deficits, motor function and daily life quality of patients.
Keywords: mesenchymal stem cells, routine medication, ischemic stroke, meta-analysis“
Read more: https://www.dovepress.com/mesenchymal-stem-cell-transplantation-as-an-effective-treatment-strate-peer-reviewed-article-TCRM
“Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC.
We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine.
Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ‘best of breed’ new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand.
Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.“