Mechanical Stretching Boosts Expansion and Regeneration of Intestinal Organoids Through Fuelling Stem Cell Self-Renewal
Researchers have discovered that cyclic stretches induce organoid growth and regeneration in a strain-dependent manner. This work offers a new perspective on optimizing organoid generation systems through understanding cross-talk between biotic and abiotic factors, providing potential approaches for the application of mechanical forces in organoid-based models.
Meng, F., Shen, C., Yang, L. et al. Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regen 11, 39 (2022).